PubMed · 499620
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
R V McCloskey. 1979. Newer penicillins.. https://pubmed.ncbi.nlm.nih.gov/499620/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
The first part of this account of the discovery of penicillin, published in last month's issue of TIBS, concluded with the detection of 6-beta-amino-penicillanic acid (6-APA), the nucleus of the penicillin structure. The exploitation of 6-APA led to the preparation of a range of clinically important semi-synthetic penicillins, which is described in this article.
The synthesis and antibacterial activity of a series of penicillins and 6 alpha-formamidopenicillins containing a C(5) or C(6)-substituted piperazine-2,3-dione moiety in the C(6)-beta-sidechain is described.
Explore the source record for details and available documents.