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Kinetic parameter estimation by numerical algorithms and multiple linear regression: application to pharmacokinetics.

K C Yeh·K C Kwan
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Abstract

Two numerical examples are presented to illustrate the application of the proposed method of parameter estimation in pharmacokinetics. Results for a system exemplifying first-order kinetics indicate that parameters estimated by the proposed procedure compare favorably with those estimated by a nonlinear regression method. In a simulated example characterized by Michaelis-Menten elimination kinetics, the accuracy of the estimated parameters was comparable to that expected, verifying the validity of the method. The importance of the numerical approximation algorithms was demonstrated also.

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BibTeXRIS

K C Yeh, K C Kwan. 1979. Kinetic parameter estimation by numerical algorithms and multiple linear regression: application to pharmacokinetics.. https://doi.org/10.1002/jps.2600680916

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