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Changes in CDP-diglyceride:inositol transferase activity during rabbit lung development.

J E Bleasdale·P Wallis·P C MacDonald·J M Johnston
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Abstract

During fetal and neonatal development the specific activity of the enzyme, CDP-diglyceride:inositol transferase in rabbit lung tissue increased 8- to 9-fold from day 17 of gestation to adulthood. This developmental increase in enzyme activity was not specific for lung tissue since a similar increase was also observed in liver tissue. The properties of CDP-diglyceride:inositol transferase in microsomes prepared from either fetal or adult rabbit lung tissue appeared to be the same. The increase in CDP-diglyceride:inositol transferase activity in rabbit lung tissue during development appeared to be reflective of synthesis of new enzyme rather than activation of pre-existing enzyme.

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AnimalsAnimals, NewbornCytidine Diphosphate DiglyceridesFetusLiverLungPhosphotransferasesRabbitsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J E Bleasdale, P Wallis, P C MacDonald, J M Johnston. 1979. Changes in CDP-diglyceride:inositol transferase activity during rabbit lung development.. https://doi.org/10.1203/00006450-197910000-00022

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