PubMed · 5109753
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S Vaisrul. 1971-09-13. Target for tocopherol.. https://doi.org/10.1001/jama.217.11.1545b
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In order to demonstrate the consequences of intrauterine haematoma demonstrated by ultrasound in hospitalised patients with imminent abortion, the course of pregnancy and delivery in patients with demonstrated intrauterine haematoma and patients in whom intrauterine haematoma could not be demonstrated were compared retrospectively. Intrauterine haematoma was demonstrated in 29% of patients with immiment abortion in The Department of Gynaecology and Obstetrics in Herlev Hospital. Patients with intrauterine haematoma were hospitalised more frequently and for more prolonged periods for imminent abortion and for imminent premature delivery. On the other hand, no differences were found in the frequencies of abortion, the birth weights, gestational age on delivery, number of preterm deliveries, frequencies of Caesarean section and adherent placenta between the two groups. Therapeutic bias may have been the cause of the increased number of days of hospitalisation in patients with intrauterine haematoma demonstrated by ultrasound.
The prognostic predictive value of maternal serum CA125 measurement was investigated in 25 cases of threatened abortion. The women were non-smoker, had a ultrasonographically verified viable single fetus, and the gestational ages ranged from 7 to 12 weeks. Twenty-five healty pregnant women, with the same characteristics were used as the control group. The overall abortion rate was found to be 20% (5/25) in the study group. In serial measurements the mean serum CA125 level of the patients with an unfavorable pregnancy outcome was significantly higher than that of the patients with a favorable outcome. When the cut-off level of maternal serum CA125 was taken as > 65 U/ml in the first and > 60 U/ml in the second measurements of the study group, the risk of termination of the pregnancy by spontaneous abortion was 83.3% in the patients with elevated serum CA125 levels. No statistically significant difference was observed with respect to the duration of vaginal bleeding between the aborters and the patients with a favorable outcome. Nevertheless, when vaginal bleeding had been present for 3 days or more and there was high maternal serum CA125 activity, the abortion risk was found to be 100% (3/3). These findings suggest that the maternal serum CA125 measurement in threatened abortion can be useful to determine the extent of decidual destruction which is directly related to the outcome of pregnancy.
In this study, we compared the incidence of fetomaternal hemorrhage between patients with threatened abortion and a control population of similar gestational age. The study population comprised pregnant patients at less than 20 weeks' gestation who presented to our emergency room with a history of vaginal bleeding without cervical dilatation or passage of tissue. The control population consisted of women presenting for elective pregnancy termination; they were excluded from the study if they gave a history of any antepartum bleeding. The amount of fetomaternal hemorrhage was evaluated using the Kleihauer-Betke acid elution assay. A positive result in our laboratory, as determined by a nonpregnant control group, was a value of 0.07% or more fetal cells. Using this criterion, 11% of the study population had a positive Kleihauer-Betke test, compared with 4% in the pregnant control group. Rho(D) immunoglobulin may be indicated in Rho(D)-negative patients who present with threatened abortion.