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Urinary pepsinogen isozymes: a highly polymorphic locus in man.

R T Taggart·R C Karn·A D Merritt·P L Yu·P M Conneally
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Abstract

A genetic analysis of human urinary pepsinogen isozymes is presented. Nine discrete phenotypes were identified in a population survey of 215 unrelated Caucasian individuals. The phenotypes were characterized by differences among the staining intensities of the activated group I pepsinogens, Pg 5, Pg 4, Pg 3, and Pg 2. The genetic studies demonstrated that the codominant expression of four alleles, PgA, PgB, PgC and PgD, at a single genetic locus determined the nine phenotypes identified. Linkage analysis excluded close linkage of the Pg locus with the chromosome 6 markers HLA, GLO1, and Bf.

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Genetic LinkageHumansIsoenzymesPepsinogensPhenotypePolymorphism, GeneticJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R T Taggart, R C Karn, A D Merritt, P L Yu, P M Conneally. 1979. Urinary pepsinogen isozymes: a highly polymorphic locus in man.. https://doi.org/10.1007/bf00271578

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