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Letter: Benign prostatic hyperplasia, prostatic cancer, and carcinogenesis.

I D Rotkin
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Age FactorsAgedHumansMaleMiddle AgedProstatic HyperplasiaProstatic NeoplasmsJournal Article

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I D Rotkin. 1975-08-23. Letter: Benign prostatic hyperplasia, prostatic cancer, and carcinogenesis.. https://doi.org/10.1016/s0140-6736(75)92792-0

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The medical records of 84 postmenopausal women treated with oral norethisterone acetate (NTA) for advanced breast cancer were retrospectively analyzed. Treatment was devoid of significant toxicity. Twenty-one patients were not evaluable for treatment response either because of insufficient data or inadequate treatment trial. Complete plus partial response was obtained in 21 (33.3%) of the 63 evaluable patients, with a median duration of 10 months. Disease stabilization was observed in 16 (25.4%) patients for a median duration of 5 months, while 26 patients (41.3%) showed progressive disease while on treatment. The best response was observed in women with dominant soft part disease and an age over 70 (CR+PR 48%). The literature on norethisterone acetate is reviewed and compared with present results. The role of progestational agents in the treatment of advanced mammary carcinoma is discussed.

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