Discontinuous absorption processes in pharmacokinetic models.

R Süverkrüp

doi:10.1002/jps.2600681115

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Discontinuous absorption processes in pharmacokinetic models.

R Süverkrüp

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Abstract

The limited contact time of absorbable drug with absorbing surfaces is, in some cases, a significant factor determining the fraction of the dose absorbed. A simple modification of customary linear compartmental models is presented to account for this situation, and a general input function in the Laplace domain for truncated first-order absorption is derived. An extension to series of truncated absorption processes is discussed.

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R Süverkrüp. 1979. Discontinuous absorption processes in pharmacokinetic models.. https://doi.org/10.1002/jps.2600681115

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