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Possible cellular events in leukemia.

W O Weigle·J M Chiller·J A Louis·G S Habicht
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Abstract

An immunologically unresponsive state induced in experimental animals can be modulated by a number of procedures. Such modulation can result in the termination of the unresponsive state if there exists a normal complement of immunocompetent B cells in the presence of unresponsive T cells. It is possible to bypass the T cells and activate the B cells to respond to otherwise tolerated antigens. The bypass results from supplying a second (nonspecific) signal to the B cells, which, in the presence of antigen (specific signal), permits the B cell to differentiate. The role of the T and B cells and their activation and/or inactivation in the fate of both leukemic cells and oncogenic viruses is discussed.

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Adjuvants, ImmunologicAnimalsAnimals, NewbornAntibody FormationB-LymphocytesBlood ProteinsCross ReactionsGraft vs Host ReactionHumansImmune ToleranceImmunity, CellularLeukemiaPolysaccharides, BacterialSerum AlbuminT-Lymphocytesgamma-GlobulinsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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W O Weigle, J M Chiller, J A Louis, G S Habicht. 1975. Possible cellular events in leukemia.. https://doi.org/10.1159/000397545

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