PubMed · 5181945
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
A B Cadorna. Nursing care study.. https://pubmed.ncbi.nlm.nih.gov/5181945/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Chronic inflammation and granuloma formation are associated with mononuclear cell infiltrates and are characteristic pathologic responses in tuberculosis. To identify host cell genes involved in tuberculous pathology, we screened macrophage cDNA libraries for genes induced by mycobacterial infection. One gene isolated in this screen, osteopontin (also known as early T lymphocyte activation protein 1 or Eta-1), was of particular interest because it is a cytokine and macrophage chemoattractant. Further study revealed that Mycobacterium tuberculosis infection of primary human alveolar macrophages causes a substantial increase in osteopontin gene expression. Osteopontin protein was identified by immunohistochemistry in macrophages, lymphocytes, and the extracellular matrix of pathologic tissue sections of patients with tuberculosis. Increased osteopontin expression also was found to be associated with silicosis, another granulomatous disease. The association of osteopontin with granulomatous pathology, together with the known properties of the protein, suggest that osteopontin may participate in granuloma formation. The strategy of identifying host genes whose expression is altered by infection thus can provide valuable clues to disease mechanisms and will be increasingly valuable as additional human genome sequences become available.
Explore the source record for details and available documents.
Over a 7-year period 68 patients with oesophageal carcinoma underwent transhiatal oesophagectomy, utilizing blunt dissection in 42 cases and eversion stripping in 26. The effects of the alternative techniques on mortality and morbidity have been analysed. There was no significant difference between the two techniques in terms of operative blood loss or time or the number of patients requiring post-operative ventilatory support. Stripping of the oesophagus was associated with significantly fewer cardiorespiratory complications and a shorter hospital stay. There was no significant difference in either 30-day or 3-month survival. Eversion stripping should become the preferred method of oesophageal resection once the primary tumour has been mobilized.