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Pulmonary function in rabbits with BCG-induced lung disease.

R P McGovern·M B Maron·C A Dawson·V L Moore·J C Garancis·D P Schlueter·J N Fink
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Abstract

This study was performed to determine whether the lung histological changes which occur in rabbits following intravenous injection of killed Bacilli Calmette-Guérin (BCG) are accompanied by measurable changes in pulmonary function. We measured pulmonary function in New Zealand white rabbits 3 weeks after intravenous injection of BCG and in normal rabbits. After a tracheostomy and carotid artery catheterization was performed, each anesthetized rabbit was placed in a body plethysmograph for pulmonary function testing. Following the measurements, the lungs were removed for weighing and histological evaluation. In the BCG-treated rabbits, the lung weight/body weight ratios were 152% greater, the pulmonary resistance was 104% higher, dynamic compliance was 45% lower, minute ventilation was 28% greater, and the delta AaPO2 gradient was 13 torr higher than in the normal control rabbits. Histological evaluation of the BCG-treated animals revealed diffuse pulmonary involvement with non-caseating granulomas.

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Airway ResistanceAnimalsBCG VaccineBlood Gas AnalysisDisease Models, AnimalFemaleLungLung ComplianceMalePneumoniaRabbitsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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BibTeXRIS

R P McGovern, M B Maron, C A Dawson, V L Moore, J C Garancis, D P Schlueter, J N Fink. 1979. Pulmonary function in rabbits with BCG-induced lung disease.. https://doi.org/10.1159/000194085

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