PubMed · 5268822
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1969. Doctor, boost your memory.. https://pubmed.ncbi.nlm.nih.gov/5268822/
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A neuromimetic model is presented here for the storage and recall of temporal sequences, including two fundamental properties. First, recall of a sequence is not induced by the presentation of one of its parts, but evoked by the occurrence of a contextual item representing its identity; second, this reproduction can be driven according to a varying rhythm under the control of an attentional subsystem.
A mechanism is proposed for a molecular switch that can store information indefinitely, despite the complete turnover of the molecules that make up the switch. The design of the switch is based on known types of biochemical reactions. Central to the mechanism is a kinase that is activated by phosphorylation and capable of intermolecular autophosphorylation. It is shown that such a kinase and an associated phosphatase form a bistable chemical switch that can be turned on by an external stimulus and that is not reset by protein turnover.
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