PubMed · 5276318
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
C E Biro. [Immunological tolerance].. https://pubmed.ncbi.nlm.nih.gov/5276318/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Patients suffering from lepromatous leprosy fail to develop an efficient cell-mediated immunity towards Mycobacterium leprae, the causative agent. The mechanism of such a specific T-cell tolerance to the bacillus remains a key question in the pathophysiology of leprosy. Macrophages do not show any intrinsic defect in phagocytizing and killing M. leprae or in presenting antigen to helper T-cells. On the other hand, M. leprae-reactive helper T-cells do persist in lepromatous patients, but their activation appears to prevented by active suppressor mechanisms, involving both suppressor T-cells and macrophages. The target of this specific suppression could be the interleukin 2-producing T-cell subset. A better molecular definition of M. leprae antigens, both by monoclonal antibodies and T-cell clones, should open new perspectives for further analysis of the regulation of immune responses to M. leprae.
Explore the source record for details and available documents.
Explore the source record for details and available documents.