PubMed · 5284541
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H Kubinyi. 1971. [Proscillaridin carbonates].. https://doi.org/10.1002/ardp.19713040807
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The contents of bufadienolide and borneol in 01 and 02 Liushen Pills were determined by second-derivative spectrophotometry and gas chromatography respectively. The average recover of bufadienolide by SDS was 100.12% (n = 6, RSD = 1.44%) and of borneol by GC 97.68% (n = 4, RSD = 1.32%).
In a preliminary study, carriers of hepatitis B virus were treated with Cinobufotalin, a preparation from toad, for 1-3 course of treatment. Results indicated that negative conversion rate was markedly higher in the treated groups (21.09%, 38.89%, 63.64% and 50%) than that of control groups (2.1%, 10.87%, 33.33% and 7.7% P < 0.001). By the end of treatment, positive conversion rate of anti-HBs and anti-HBe were also markedly higher in the former (19.29% and 23.45%) than that in the latter (4.26% and 7.14% P < 0.001). During the follow-up of 3-6 months, the positive rate of HBeAg in treated group (50%) raised as compared with the control group (20% P = 0.08). The results indicated that Cinobufotalin had a significant effect in inhibiting the replication of HBV.
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