Drug elimination interactions: analysis using a mathematical model.

R H Luecke; W D Wosilait

doi:10.1007/bf01061211

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Drug elimination interactions: analysis using a mathematical model.

R H Luecke·W D Wosilait

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Abstract

A mathematical model was developed to analyze the elimination kinetics of drug interactions in the rat. The model is based on physiological blood flow rates and organ weights and includes Michaelis-Menten equations for enzymatic processes which are involved in the elimination of the drug; competitive inhibition interactions are computed for shared pathways. Using data from the single drugs, the model can simulate the results of experiments of the acute warfarin-BSP interactions in rats.

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Animals Drug Interactions Kinetics Male Models, Biological Pharmaceutical Preparations Rats Sulfobromophthalein Time Factors Warfarin Journal Article Research Support, U.S. Gov't, P.H.S.

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R H Luecke, W D Wosilait. 1979. Drug elimination interactions: analysis using a mathematical model.. https://doi.org/10.1007/bf01061211

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