Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells.

C David; T Meo; J McCormick; D Shreffler

doi:10.1084/jem.143.1.218

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Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells.

C David·T Meo·J McCormick·D Shreffler

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Abstract

Ia specificities 1-10 were detected on LPS-stimulated splenic lymphocytes and on Con A-stimulated spleen, lymph node, and thymus blasts by direct cytotoxic tests. Since Ia antigens are not readily detectable on resting thymocytes, our results suggest that T cells require some signal before they exhibit full expression of Ia specificities. Absorption-elution studies indicated that most of the Ia specificities detected on T and B cells may be identical. Ia antigens detected by homologous antisera gave much stronger reactions than those detected by cross-reacting antisera.

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Animals Antigens B-Lymphocytes Cross Reactions Epitopes Lipopolysaccharides Lymph Nodes Lymphocyte Activation Lymphocytes Mice Mice, Inbred Strains Spleen T-Lymphocytes Thymus Gland Journal Article Research Support, U.S. Gov't, P.H.S.

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C David, T Meo, J McCormick, D Shreffler. 1976-01-01. Expression of individual Ia specificities on T and B cells. I. Studies with mitogen-induced blast cells.. https://doi.org/10.1084/jem.143.1.218

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