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Comparative studies with three antibiotics binding to deoxyribonucleic acid.

F Reusser·B K Bhuyan
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Abstract

The effects of the three antibiotics U-12,241, nogalamycin, and U-20,661 on (i) deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) synthesis in KB cell cultures and cell-free systems of bacterial and mammalian origin and on (ii) oxidative phosphorylation in rat liver mitochondria were compared. Nogalamycin and U-12,241 inhibited RNA synthesis more strongly than DNA synthesis in all test systems. Antibiotic U-20,661 inhibited DNA and RNA synthesis equally in whole mammalian cells and their corresponding cell-free systems. The RNA polymerase from Escherichia coli, however, was at least 100 times more sensitive to U-20,661 than was the DNA polymerase. U-12,241 caused significant uncoupling of oxidative phosphorylation in mitochondria.

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AnimalsAnti-Bacterial AgentsDNA, BacterialEscherichia coliMitochondriaNucleotidyltransferasesOxygen ConsumptionRNA, BacterialRatsComparative StudyJournal Article

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F Reusser, B K Bhuyan. 1967. Comparative studies with three antibiotics binding to deoxyribonucleic acid.. https://doi.org/10.1128/jb.94.3.576-579.1967

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