PubMed · 5366065
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K Suzuki, M Matsuishi, T Ozeki, H Nakamura, A Takahashi. 1969. [Dumping syndrome].. https://pubmed.ncbi.nlm.nih.gov/5366065/
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Dumping syndrome in infancy is a rare complication following gastric surgery. We describe an 11-month-old infant affected by recurrent peptic oesophagitis who underwent a combined Nissen fundoplication and pyloroplasty. Early dumping symptoms such as irritability, pallor, sweating, abdominal distension and watery diarrhoea were observed postoperatively after bolus feeding. Gastric emptying, measured after the administration of 150 ml of regular cow milk mixed with 200 microCi (8 MBq) of technetium-99m sulfur colloid (99mTc-SC), demonstrated an early rapid and massive emptying of the isotopes into the small intestine, followed by duodenogastric reflux and a second wave of emptying and reflux at 9 min. The initial pattern of gastric emptying and duodenogastric reflux was followed by a slow emptying phase with half-emptying time of 81 min. Isotope studies should be used to investigate motility disorders caused by this type of anti-reflux operation.
An analysis of long-term results of surgical treatment (resection of the stomach) of 92 patients with noncomplicated ulcer of the duodenum has been made 10 years after the operative procedure. Peptic ulcer of the gastroenteroanastomosis was found to develop in 1 of 92 patients. The first group (after Vizik) included 23 patients (25%); the second group--22 patients (23.9%), the third one--44 (47.8%) and the fourth--3 patients (3.3%). As a whole, excellent and good results of gastric resection for noncomplicated duodenal ulcer were noted but in half of the patients.
The effect of cyclic somatostatin on early and late dumping syndrome was studied in 12 patients with gastric resection. Each patient underwent two glucose challenges with 75 grams of glucose administered orally. In the control study isotonic sodium chloride was given, while in the other study cyclic somatostatin in a dose of 250 micrograms bolus injection followed by infusion of 80 ng/kg/min for a period of 270 minutes. In the control study all patients showed subjective symptoms of the early dumping syndrome with significant increases in pulse rate, hematocrit, and vasoactive intestinal polypeptide. Ten patients showed asymptomatic hypoglycemia, as a sign of the late dumping syndrome associated with a significant increases of insulin, gastric inhibitory peptide and glucagon levels. During the administration of somatostatin these changes failed to develop. These results indicate that somatostatin alleviates the symptoms of early and late postprandial dumping syndrome.