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A new hepatitis B virus surface antigen.

J Shorey
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Abstract

A new determinant of hepatitis B surface antigen (HBs Ag), g, which is distinct from the previously identified determinants a, d, y, w, and r, was studied. This new antigen tended to be associated with the d antigen; it was found in 97% of ad specimens and in 15% of ay specimens. With few exceptions, the atypical subtypes, adg- and ayg+, were identified in sera from blood donors, but not in sera from patients with acute viral hepatitis; this finding possibly reflects a reduced tendency of these viral strains to evoke a host immune response. The ability to identify g represents a refinement of HBs Ag serotyping that may be of value in the study of the epidemiology of hepatitis B virus.

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Cell MembraneEpitopesHepatitis AHepatitis B AntigensHepatitis B virusHumansRadioimmunoassaySerotypingJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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J Shorey. 1976. A new hepatitis B virus surface antigen.. https://doi.org/10.1093/infdis%2F133.1.1

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