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PubMed · 5483385

Thermal damage to red cells.

S Baar·D J Arrowsmith
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Abstract

Erythrocytes from a burned patient show a temporal sequence of morphological changes. Immediate severe changes occur which are followed by a transient phase only of less abnormal morphology. Heating whole blood in vitro to 49 degrees C instead of 50 degrees C does not show the expected dose response curve. Heating whole blood in vitro to 50 degrees C induces progressive morphological changes. Fractionation of whole blood and subsequent heating to 48 degrees C show the older cells to be less deformable.

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BurnsChild, PreschoolErythrocytesHot TemperatureHumansIn Vitro TechniquesMicroscopy, Electron, ScanningJournal Article

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S Baar, D J Arrowsmith. 1970. Thermal damage to red cells.. https://doi.org/10.1136/jcp.23.7.572

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Comprehensive Analysis of Differentially Expressed Genes and Immune Infiltration in Burn Injury: Key Biomarkers and Pathways.

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Burns↗
PubMed2007

Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients.

OBJECTIVE: To determine the risk of developing sepsis following transfusion of blood products in severely burned pediatric patients. DESIGN: Retrospective, cohort study. SETTING: Shriners Hospital for Children and University Hospital. PATIENTS: Severely burned pediatric patients with >30% total body surface area (TBSA) burn. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Two hundred seventy-seven pediatric burn patients over a period of 7 yrs (1997-2004) were included in the study, with 25 patients being septic at admission and therefore excluded. Patients were stratified according to TBSA burn and presence or absence of inhalation injury. The amounts of packed red blood cells (RBCs) and fresh frozen plasma (FFP) were recorded during hospital stay before the development of sepsis. Blood product administration was normalized for the number of surgeries and divided into two groups: high (RBCs>20/FFP>5) or low (RBCs<20/FFP<5) amount of blood products. Sepsis was diagnosed based on the criteria set by the Society of Critical Care Medicine in conjunction with positive blood culture or presence of organisms in the organs at autopsy. By stratifying the groups into low and high blood transfusion, we found that patients with >60% TBSA burn with inhalation injury have an 8% risk of developing sepsis in the low RBC group, which increases to 58% in the high RBC group (p<.05). Similar results were found for RBCs per operation, FFP, and FFP per operation (p<.05). There were no differences in age and gender between groups. CONCLUSIONS: Pediatric burn suffering from a 60% TBSA burn with concomitant inhalation injury are more likely to develop sepsis if they are given high amounts of blood products, indicating an immunocompromised state following blood transfusion.

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