PubMed · 54843
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R H Seder, P M Desai, R S Keff. 1975-12-27. Letter: Laboratory-acquired hepatitis B.. https://doi.org/10.1016/s0140-6736(75)90662-5
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To evaluate the histological effects of alpha Interferon (IFN) therapy, serial liver biopsy specimens from 30 patients with chronic hepatitis were studied. The biopsies were examined using a scoring system. After 12 mths of IFN therapy responders were 8 out of 11 HBV infected patients, 10 out of 12 HCV infected patients and only 1 out of 7 patients with cryptogenetic hepatitis. As spontaneous improvement of hepatic changes is infrequent, our data indicate that in terms of histological patterns interferon therapy is effective in chronic viral hepatitis.
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