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PubMed · 5496613

[Immunosuppressive treatment].

A Mani
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Antilymphocyte SerumHumansImmune ToleranceImmunosuppressive AgentsRadiation EffectsJournal Article

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A Mani. 1970-06-15. [Immunosuppressive treatment].. https://pubmed.ncbi.nlm.nih.gov/5496613/

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Allogeneic stem cell transplantation in a patient with dyskeratosis congenita after conditioning with low-dose cyclophosphamide and anti-thymocyte globulin.

Bone marrow failure is the major cause of early mortality in patients with dyskeratosis congenita (DC); early trials with conventional conditioning regimens were associated with remarkable chronic morbidity and mortality, and the optimal conditioning regimen for these patients remains undetermined. We report a case of a child afflicted with DC who underwent related full HLA-matched stem cell transplant (SCT) using a regimen of low dose cyclophosphamide and antithymocyte globulin (ATG). The regimen was well tolerated and associated with no significant short-term toxicity.

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