PubMed · 552441
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H S Jacobs. 1979. Hormone replacement therapy.. https://doi.org/10.1177/014107687907201101
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In 1981 Greenway and co-authors reported the existence of estrogen receptor in tumor tissue of the pancreas. We have tried hormone therapy using tamoxifen in 4 of 11 patients with unresectable carcinoma of the pancreas in whom expandable metallic stents were inserted for the palliation of obstructive jaundice. The mean survival period in these 4 patients was 235 days, and 2 of them had a remarkably long survival of 321 and 463 days respectively. On the other hand, the mean survival was 128 days in 7 control patients. We therefore evaluated this new therapy with tamoxifen as effective in patients with unresectable carcinoma of the pancreas.
Grant (1990) reported significantly higher dominance scores during pregnancy of mothers who later bore sons than mothers who later bore daughters. Such findings have been reported in other species, and evidence is adduced here to suggest that this difference is not wholly a temporary effect of the pregnancy but probably pre- and post-dates the pregnancy.