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PubMed · 5539204

Allergic encephalomyelitis: new form featuring polymorphonuclear leukocytes.

S Levine·R Sowinski
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Abstract

The passive transfer of allergic encephalomyelitis can be produced in a single day. In work described, the procedure was made to coincide with a transient drug-induced deficiency of lymphocytes. As a result, the lesions of this autoimmune disease contained a predominance of polymorphonuclear leukocytes instead of the usual mononuclear cells. Not only is this a new histologic form of the disease, but the ready recognition of polymorphonuclears as reactive cells provides a powerful new tool for investigating the roles of immunologically specific effector cells and nonspecific reactive cells in production of tissue damage.

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AnimalsAutoimmune DiseasesCyclophosphamideEncephalomyelitis, Autoimmune, ExperimentalFemaleFreund's AdjuvantGuinea PigsLymph NodesLymphopeniaNeutrophilsPertussis VaccineRatsSpinal CordJournal Article

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S Levine, R Sowinski. 1971-02-05. Allergic encephalomyelitis: new form featuring polymorphonuclear leukocytes.. https://doi.org/10.1126/science.171.3970.498

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