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PubMed · 5573409

Macroamylasemia: rapid detection method.

L Fridhandler·J E Berk·M Ueda
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AmylasesBlood ProteinsCarbohydrate Metabolism, Inborn ErrorsChromatography, GelClinical Enzyme TestsCytochromesDextransHumansIodineMass ScreeningMethodsMolecular WeightPolysaccharidesJournal Article

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L Fridhandler, J E Berk, M Ueda. 1971. Macroamylasemia: rapid detection method.. https://pubmed.ncbi.nlm.nih.gov/5573409/

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PubMed1992

Effects of calyculin A on amylase release in streptolysin-O permeabilized acinar cells.

The effects of the phosphatase inhibitors calyculin A and okadaic acid on amylase release from streptolysin-O permeabilized rat pancreatic acini were investigated. Both agents induced similar biphasic effects with moderate potentiation of calcium-stimulated amylase release at medium and strong inhibition at higher concentrations. Calyculin A was thirty times more potent than okadaic acid and at 100 nM totally inhibited calcium-induced amylase release while 3 microM okadaic acid reduced amylase release by 78%. 100nM calyculin A also completely inhibited GTP gamma S-potentiated amylase release and partially inhibited phorbol ester potentiated secretion. The data indicate that inhibition of a serine/threonine phosphatase, probably a type 1 phosphatase, leads to inhibition of calcium-induced amylase release in permeabilized pancreatic acini.

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