5'-Terminal structure and mRNA stability.

Y Furuichi; A LaFiandra; A J Shatkin

doi:10.1038/266235a0

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5'-Terminal structure and mRNA stability.

Y Furuichi·A LaFiandra·A J Shatkin

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Abstract

Reovirus mRNAs with 5'terminal m7GpppGm or GpppG are more stable than mRNA containing unblocked ppG 5'-ends when injected into Xenopus laevis oocytes or incubated in cell-free protein synthesising extracts of wheat germ and mouse L cells. The greater stability of mRNA with blocked 5' termini is not dependent upon translation but seems to result from protection against 5'-exonucleolytic degradation.

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Animals Base Sequence Cell-Free System Exonucleases Female Guanine Nucleotides L Cells Methyltransferases Molecular Weight Oocytes Protein Biosynthesis RNA, Messenger RNA, Viral Reoviridae Reticulocytes Structure-Activity Relationship Triticum Xenopus Journal Article

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Y Furuichi, A LaFiandra, A J Shatkin. 1977-03-17. 5'-Terminal structure and mRNA stability.. https://doi.org/10.1038/266235a0

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