PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 5594784

[Integerressin and integerrenin, two peptide alkaloids from Ceanothus integerrimus Hook. and Arn].

R Tschesche·J Rheingans·H W Fehlhaber·G Legler
View original source ↗Export metadata ↓

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

AlkaloidsPeptidesPlantsSpectrum AnalysisJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

R Tschesche, J Rheingans, H W Fehlhaber, G Legler. 1967. [Integerressin and integerrenin, two peptide alkaloids from Ceanothus integerrimus Hook. and Arn].. https://doi.org/10.1002/cber.19671001213

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2003

A concise asymmetric route to Nuphar alkaloids. A formal synthesis of (-)-deoxynupharidine.

[reaction: see text] A stereocontrolled route to Nuphar alkaloids is described that employs a formal [3 + 3] cycloaddition strategy to assemble the piperidine nucleus. The addition of Pd-TMM complexes to aziridine 10 was found to be sluggish; however, the addition of a functionalized allyl Grignard reagent followed by a Mitsunobu condensation reaction provided 11 in high yield. The employment of this route in the formal synthesis of (-)-deoxynupharidine 1 is described.

Alkaloids↗
PubMed2003

Concise formal synthesis of (-)-peduncularine via ring-closing metathesis.

[reaction: see text] A synthesis of the 6-aza[3.2.1]bicyclooctene (-)-2 has been completed by a short sequence of reactions that required only six operations from (S)-malic acid and featured a novel ring-closing metathesis to form the bridged bicyclic ring. Because 2 was previously converted into (-)-peduncularine (1), its preparation constitutes a formal enantioselective synthesis of 1.

Alkaloids↗
PubMed2003

Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots.

Camptothecin (CPT) is an anticancer and antiviral alkaloid produced by the Chinese tree Camptotheca acuminata (Nyssaceae) and some other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae. Bark and seeds are currently used as sources for the drug. Several attempts have been made to produce CPT from cell suspensions; however, the low yields obtained limit this approach. Cultures of differentiated cell types may be an alternative source of alkaloid production. Hairy root cultures of C. acuminata were established from tissue transformed with Agrobacterium rhizogenes strains ATCC 15834 and R-1000. Integration of the genes responsible for the hairy-root phenotype ( rol genes) into the plant genome was verified by DNA gel blot analysis. The hairy roots produce and secrete CPT as well as the more potent and less toxic natural derivative, 10-hydroxycamptothecin (HCPT), into the medium. Remarkably, the cultures were able to synthesize the alkaloids at levels equal to, and sometimes greater than, the roots in planta, i.e., 1.0 and 0.15 mg/g dry weight for CPT and the HCPT, respectively.

Alkaloids↗