Clindamycin in infective endocarditis.

C E Cherubin; S R Nair

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PubMed · 563932

Clindamycin in infective endocarditis.

C E Cherubin·S R Nair

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Abstract

Because of problems of penicillin allergy or lack of veins for intravenous administration of antibiotics, nine patients with endocarditis were treated with clindamycin, administered intramuscularly. Five patients were heroin addicts with staphylococcal endocarditis and four had alpha-streptococcal endocarditis. The only therapeutic failure occurred in a patient with a strain of Staphylococcus aureus that became resistant to clindamycin in vivo. Such resistance has been reported to occur in vitro, and testing for it should prove useful in proper selection of cases for treatment with clindamycin, an agent that appears to be effective in selected cases of endocarditis.

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Clindamycin Endocarditis, Bacterial Humans Injections, Intramuscular Staphylococcal Infections Staphylococcus aureus Streptococcal Infections Substance-Related Disorders Journal Article

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C E Cherubin, S R Nair. 1978-02-13. Clindamycin in infective endocarditis.. https://pubmed.ncbi.nlm.nih.gov/563932/

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