PubMed · 5650239
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A A Torres. 1968. Alpha blocking "conditioning", sensitization and interstimulus interval.. https://pubmed.ncbi.nlm.nih.gov/5650239/
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There has been much recent interest in the possibility that signals for drug use in humans acquire the ability to evoke classically conditioned (learned) states which motivate drug taking. Much data now suggest that cues paired with drug use come to elicit physiological responses and subjective reports of drug-related feelings like craving and withdrawal. However, the designs employed do not permit the conclusion that the observed responding results from classical conditioning. Studies which look directly at conditioning in the laboratory by pairing neutral stimuli with drug administration have not provided appropriate controls for unlearned effects such as sensitization or pseudo-conditioning. Similarly, studies which assess responding to cues thought to signal drug use in the natural environment (e.g., the sight of someone injecting heroin) have not adequately assessed whether such cues have unconditioned (unlearned) effects. Determining whether responding to drug-related cues results from classical conditioning has important implications for the development of drug treatments. Consequently, the purpose of the present review is to outline a set of criteria for determining that responses to drug-related stimuli in humans are learned. Existing studies are reviewed in light of these criteria and paradigms for further work are suggested.
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Pain is a common problem for patients with terminal illnesses. The major efforts to control pain for these patients have focused on the appropriate uses of analgesic medication to reduce the sensory aspect of the pain experienced. There are a number of studies in the chronic pain literature, however, that have implicated the important role of a number of psychological factors in the maintenance and exacerbation of pain. Among the most important variables identified are expectancy, anxiety, perceived controllability, self-efficacy, symptom preoccupation, operant conditioning, classical conditioning, and observational learning. In this paper, these psychological variables are examined and their applicability to patients who have pain associated with terminal illnesses is discussed as well as the implications of these variables for complementary treatment with analgesic medications are described.