Brain noradrenergic systems as a prerequisite for developing tolerance to barbiturates.

B Tabakoff; J Yanai; R F Ritzmann

doi:10.1126/science.565533

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PubMed · 565533

Brain noradrenergic systems as a prerequisite for developing tolerance to barbiturates.

B Tabakoff·J Yanai·R F Ritzmann

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Abstract

Mice treated with 6-hydroxydopamine before they were chronically fed phenobarbital did not develop functional barbiturate tolerance, measured by duration of the loss of righting reflex and hypothermia. Injection of 6-hydroxydopamine caused significant depletion of brain norepinephrine, while brain dopamine levels were not significantly depleted. Intact brain noradrenergic systems seem to be necessary for developing tolerance to the hypnotic and hypothermic effects of the barbiturates.

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Animals Behavior, Animal Body Temperature Regulation Brain Drug Tolerance Humans Hydroxydopamines Male Mice Norepinephrine Phenobarbital Reflex Substance Withdrawal Syndrome Substance-Related Disorders Sympathetic Nervous System Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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B Tabakoff, J Yanai, R F Ritzmann. 1978-04-28. Brain noradrenergic systems as a prerequisite for developing tolerance to barbiturates.. https://doi.org/10.1126/science.565533

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