Glutamic acid and ethanol dependence.

W J Freed; E K Michaelis

doi:10.1016/0091-3057(78)90379-9

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PubMed · 566932

Glutamic acid and ethanol dependence.

W J Freed·E K Michaelis

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Abstract

Glutamate diethyl ester, a specific glutamate antagonist, attenuated the seizures and decreases in behavioral activity that were observed in mice during withdrawal. Prior to withdrawal, ethanol-dependent animals were supersensitive to kainic acid, a potent glutamate agonist, but they were not supersensitive to the convulsant drug pentylenetetrazol. These findings suggest that supersensitivity to glutamate develops during ethanol dependence, and that this phenomenon contributes to the signs of ethanol withdrawl.

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Alcoholism Animals Brain Chemistry Ethanol Excitatory Amino Acid Antagonists Glutamates Humans Kainic Acid Male Mice Motor Activity Pentylenetetrazole Seizures Substance Withdrawal Syndrome Time Factors Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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W J Freed, E K Michaelis. 1978. Glutamic acid and ethanol dependence.. https://doi.org/10.1016/0091-3057(78)90379-9

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