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PubMed · 567736

Trimethoprim-resistant bacteria: cross-resistance patterns.

D Grey·J M Hamilton-Miller
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Abstract

One hundred and eighty one strains (clinically isolated) of trimethoprim-resistant bacteria were tested for sensitivity to proguanil, pyrimethamine, methotrexate and methasquin. All these agents had less intrinsic antibacterial activity than trimethoprim, and there was marked cross-resistance between trimethoprim on the one hand and pyrimethamine and methasquin on the other. Methotrexate was of very low activity against Gram-negative bacilli, but was highly inhibitory for streptococci. Proguanil had approximately the same activity for all the organisms tested, and appears not to act as an anti-folate agent.

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Aspartic AcidBacteriaBacterial InfectionsCross ReactionsDrug Resistance, MicrobialHumansMethotrexateProguanilPyrimethamineR FactorsSpecies SpecificityTrimethoprimUrineJournal Article

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D Grey, J M Hamilton-Miller. 1977. Trimethoprim-resistant bacteria: cross-resistance patterns.. https://pubmed.ncbi.nlm.nih.gov/567736/

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