PubMed · 5717673
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C Person, D T Suzuki. 1968. Chromosome structure--a model based on DNA replication.. https://doi.org/10.1139/g68-081
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The stamen-hair system of Tradescantia heterozygous for flower color (blue/pink, the pink color being recessive) is an excellent botanical tester of mutagenicity. It is especially useful for detection of the genetic effects of both ionizing radiations and chemical mutagens at the low levels of exposure to which the human population may actually be exposed. This system exhibits a high accuracy in laboratory experiments, and is also applicable for in situ monitoring in the environment. The use of the Tradescantia stamen-hair system is inexpensive and requires only a short training time. Simplified scoring methods which endorse a high statistical accuracy have newly been developed to score larger samples of pink somatic mutations. In the present paper, the most widely used clones, methods for their cultivation, and use in a variety of experiments with radiations and chemical mutagens are also reviewed.
Under the assumption of no chromatid interference, we derive constraints on the probabilities of the different recombination patterns among m + 1 genetic loci. An application of these constraints is a proof that the ordering of the loci that maximizes the likelihood under the assumption of no interference is, in fact, a consistent estimator of the true order even when there is interference.
Mitotic HeLa cells were treated with different concentrations of okadaic acid inhibiting phosphatase 2A activity alone or in addition to phosphatase 1 activity. Phosphatase 2A inhibition alone had no visible effect on mitosis, but inhibition of both phosphatase 1 and 2A produced mitotic abnormalities, including inhibition of anaphase mimicking the effect of colchicine. Recovery experiments in okadaic acid-free medium showed formation of diplochromosomes, indicating a failure of sister chromatid separation in the treated mitotic cells. The universality of the phosphatase 1 requirement in sister chromatid separation is discussed.