Structure-anorectic activity relationships in substituted phenethylamines.

S L Beregi; J Duhault

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PubMed · 576809

Structure-anorectic activity relationships in substituted phenethylamines.

S L Beregi·J Duhault

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Abstract

A series of phenylisopropylamine derivatives are compared with the correspondent beta-methoxy- and beta-hydroxy-phenethylamine compounds. Unlike amphetamine, the beta-methoxy phenethylamine has no anorectic activity. This property appears only with the introduction of a CF3 group on the benzene nucleus. The racemic N-alkyl derivatives are more active than the racemic or even the levorotatory N-benzyl compound. The beta-hydroxy-phenethylamines are devoid of anorectic activity.

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S L Beregi, J Duhault. 1977. Structure-anorectic activity relationships in substituted phenethylamines.. https://pubmed.ncbi.nlm.nih.gov/576809/

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