Studies on effector cell-target cell interactions in vitro by means of the quantitative immunoadherence technique.

F Doljanski; Y Markson; S Katzav; D W Weiss

doi:10.1007/978-1-4613-4355-4_67

Home/Archive/PubMed

PubMed · 57704

Studies on effector cell-target cell interactions in vitro by means of the quantitative immunoadherence technique.

F Doljanski·Y Markson·S Katzav·D W Weiss

View original source ↗Export metadata ↓

Abstract

The source did not provide an abstract. Follow the original record for more information.

Explore related subjects

Adenocarcinoma Animals Antigens, Neoplasm Bromodeoxyuridine Cell Adhesion Chickens Cytotoxicity Tests, Immunologic Epitopes Immune Adherence Reaction Immunity, Cellular Lymphocytes Mice Neoplasm Transplantation Neoplasms Sarcoma, Avian Spleen Transplantation, Homologous Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

F Doljanski, Y Markson, S Katzav, D W Weiss. 1976. Studies on effector cell-target cell interactions in vitro by means of the quantitative immunoadherence technique.. https://doi.org/10.1007/978-1-4613-4355-4_67

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2001

Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.

The G12 subfamily of heterotrimeric G proteins, comprised of the alpha-subunits Galpha12 and Galpha13, has been implicated as a signaling component in cellular processes ranging from cytoskeletal changes to cell growth and oncogenesis. In an attempt to elucidate specific roles of this subfamily in cell regulation, we sought to identify molecular targets of Galpha12. Here we show a specific interaction between the G12 subfamily and the cytoplasmic tails of several members of the cadherin family of cell-surface adhesion proteins. Galpha12 or Galpha13 binding causes dissociation of the transcriptional activator beta-catenin from cadherins. Furthermore, in cells lacking the adenomatous polyposis coli protein required for beta-catenin degradation, expression of mutationally activated Galpha12 or Galpha13 causes an increase in beta-catenin-mediated transcriptional activation. These findings provide a potential molecular mechanism for the previously reported cellular transforming ability of the G12 subfamily and reveal a link between heterotrimeric G proteins and cellular processes controlling growth and differentiation.

Adenocarcinoma↗

PubMed1979

Bone metastases from breast cancer treated with calcitonin. Case report.

A case of bone metastases from breast cancer is reported. After 6 months of therapy with calcitonin, the skeletal radiological examination showed an evident change in the roentgenographic pattern of a large metastasis of the left femur. A possible relationship between the calcitonin treatment and the radiological change is discussed.

Adenocarcinoma↗

PubMed1979

A case of hyperthyroidism due to metastasis of a thyroid carcinoma.

A case of hyperthyroidism, which developed in a patient affected by thyroid carcinoma a few days after thyroidectomy, is described. The symptomatology was caused by a bone metastasis at the left ischiopubic branch, which had a high iodine-uptake capacity and was sensitive to metabolic radiotherapy. Pulmonary metastases were also present; they had a distinct low affinity for iodine and showed no response to repeated administrations of 131I. The case is evaluated on the basis of the evolution of the clinical picture and the hormone dosages administered in a follow-up period of 3 years.

Adenocarcinoma↗