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Ascorbic acid: cofactor in rabbit olfactory preparations.

K O Ash
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Abstract

A stimulant-induced decrease in absorbance at 267 nanometers in preparations from rabbit olfactory epithelium requires ascorbic acid as a cofactor. Vitamin C is bound to proteins in the olfactory mucosa in vivo. When the stimulant. 3,7-dimethyl-6-octen-3-ol interacts with olfactory proteins, it triggers a change in protein conformation which renders ascorbic acid available for oxidation. The specific decrease in absorbance at 267 nanometers is produced when the "freed" ascorbic acid is oxidized.

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AnimalsAscorbic AcidEpitheliumIn Vitro TechniquesOlfactory NerveOxidation-ReductionProtein BindingRabbitsSpectrophotometryStimulation, ChemicalTissue ExtractsUltraviolet RaysJournal Article

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BibTeXRIS

K O Ash. 1969-08-29. Ascorbic acid: cofactor in rabbit olfactory preparations.. https://doi.org/10.1126/science.165.3896.901

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