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Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques.

U R Rapp·R C Nowinski
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Abstract

Endogenous ecotropic type C viruses were induced by iodedeoxyuridine from nontransformed and chemically or spontaneously transformed clones of the C3H/10T1/2 cell line. Viruses produced by cells of certain transformed clones were N-tropic and formed large XC plaques. In contrast, viruses produced by nontransformed C3H/10T1/2 cells were not detectable in the XC plaque test. These XC- viruses infected mouse cells with high efficiency, as shown by the induction of murine leukemia virus group-specific antigens in infected cells, but virus production, as determined by DNA polymerase-containing particles, was extremely low. Upon growth in certain mouse cells these replication-deficient, XC(-) viruses converted to type C viruses that were similar in XC assays to N-tropic AKR virus (XC+).

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AnimalsAntigens, ViralCell LineCell Transformation, NeoplasticChick EmbryoDefective VirusesIdoxuridineLeukemia Virus, MurineMiceMice, Inbred StrainsRNA-Directed DNA PolymeraseRetroviridaeVirus ReplicationJournal Article

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U R Rapp, R C Nowinski. 1976. Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques.. https://doi.org/10.1128/jvi.18.2.411-417.1976

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