PubMed · 5853091
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A Da Fonseca. 1965. [Simple and complex eczematous processes].. https://pubmed.ncbi.nlm.nih.gov/5853091/
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A patient is described with proven delayed type allergy for heparin and a low molecular heparin. A literature survey shows that the dermatological picture varies. Occurrence of erythematous plaques without a superficial dermatitis is possible. Epicutaneous tests are often not sufficient, and intracutaneous or even subcutaneous tests are necessary to demonstrate the allergy.
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The authors describe a case of idiopathic hypereosinophilic syndrome (HES) terminated as a T-cell lymphoma in a 3-year-old girl. The clinical course was chronic and characterized by chronic eczema, persistent peripheral blood eosinophilia, organomegaly, interstitial lung change, and pericarditis. Postmortem examination demonstrated a disseminated T-cell lymphoma involving the inguinal lymph node, liver, lung, and kidney. The findings of the current case suggest a possibility that certain abnormalities in this case of idiopathic HES per se may have triggered the development of malignant lymphoma, and it may represent a transition of idiopathic HES into a T-cell lymphoma. Other possible sequences are discussed. The development of T-cell malignancy in idiopathic HES in a girl is quite an unusual presentation.