PubMed · 5881069
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A C Cremona, E G Cremona, E T Lastra. 1965. [Iridoschisis].. https://pubmed.ncbi.nlm.nih.gov/5881069/
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Fraser syndrome is a rare autosomal recessive disorder whose major manifestations are cryptophthalmos, syndactyly and genital abnormalities. These patients also frequently have malformations of the ears, nose and/or larynx. The diagnosis is usually made at birth from the obvious malformations, although occasionally made on prenatal ultrasound. Treatment is dependent on which malformations are present and genetic counseling is indicated. Prognosis is dependent on the severity of renal and laryngeal malformations.
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BACKGROUND: There are various causes of increasing ocular tension after vitrectomy and intraocular silicone oil filling; it is reported on a new type of postoperative secondary glaucoma. MATERIALS AND METHODS: A 56-year-old man with flat anterior chamber and secondary glaucoma after vitrectomy and intraocular silicone oil filling was examined; only the transpupillary inspection of the posterior surface of the iris with the three mirror contact glass yielded the decisive reference to the pathogenesis of the glaucoma. RESULTS: The secondary glaucoma was caused by small perfluoroctane bubbles blocking up Ando's peripheral iris coloboma. CONCLUSIONS: In case of an unclear pathogenesis of secondary glaucoma after vitrectomy and fluid/perfluoroctane/silicone oil exchange among others a blockade of Ando's peripheral coloboma by small perfluoroctane bubbles should be considered as a cause of increased intraocular tension.