PubMed · 58999
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
S Adler, K Shimaoka, Y Tsukada. 1976-06-28. Letter: Bleomycin toxicity.. https://doi.org/10.1001/jama.235.26.2814c
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
The reaction of Fe(II) . bleomycin with O2 to yield Fe(III) . bleomycin has been resolved into two kinetic events by stopped-flow spectrophotometry. The first event is first order with respect to both bleomycin and O2 and may be regarded as a second order reaction (k = 6.1 x 10(3) M-1s-1 at 2 degrees C). The first product has no EPR spectrum. The optical spectrum resembles those of Fe(II) . bleomycin complexes with CO, NO, and ethyl isocyanide. We propose that the first product is an Fe(II) . bleomycin . O2 complex. The second kinetic event is first order with respect to the first accumulated product (k = 0.11 s-1 at 2 degrees C) and independent of oxygen concentration. The product of this reaction is indistinguishable from Fe(III) . bleomycin by optical and EPR spectroscopy.
Explore the source record for details and available documents.
Explore the source record for details and available documents.