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Immunisation against hepatitis B in man.

P Maupas·A Goudeau·P Coursaget·J Drucker·P Bagros
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Abstract

An inactivated vaccine against hepatitis B was prepared from blood-donor HBs antigen purified on immunoadsorbents. Its safety and efficacy were tested in chimpanzees. Vaccination was then applied in an attempt to protect patients and staff in a haemodialysis unit. The efficacy of the vaccine in man was assessed by observing humoral and cellular immune reactions and by comparing changes in HBs antigenaemia in vaccinated and non-vaccinated subjects. The results indicate that this vaccine protects against hepatitis B in the circumstances in which it was administered.

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AnimalsHepatitis BHepatitis B AntigensHumansLiverPan troglodytesVaccinationViral VaccinesClinical TrialControlled Clinical TrialJournal Article

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P Maupas, A Goudeau, P Coursaget, J Drucker, P Bagros. 1976-06-26. Immunisation against hepatitis B in man.. https://doi.org/10.1016/s0140-6736(76)93023-3

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