PubMed · 5902520
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I B Goldman. 1966. Rhinoplastic sequelae causing nasal obstruction.. https://doi.org/10.1001/archotol.1966.00760020153011
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In cartilage collagen type XI exists as heterotrimeric molecules composed of alpha 1(XI), alpha 2(XI) and alpha 3(XI) subunits. Messenger RNAs for some of the alpha chains of collagen type XI have also been found in non-chondrogenic tissues but the chain composition of the molecule in these sites is not known. Some non-chondrogenic tissues also contain heterotrimers containing collagen alpha 2(V) and alpha 1(XI) chains. We have explored the possibility that collagen type XI could exist in differing trimeric forms in non-chondrogenic tissues and aimed to predict the subunit composition of this collagen in those tissues. The distribution and relative levels of expression of collagen alpha 1(XI), alpha 2(XI) and alpha 3(XI)/alpha 1(II) mRNAs in different human fetal tissues were studied. Expression of mRNAs for all three genes of collagen type XI is not restricted to cartilage but is widespread. However, in some non-chondrogenic tissues, the mRNAs for all three alpha chains of collagen type XI were not co-expressed, but collagen alpha 1(XI) and alpha 2(XI) mRNAs were found either singly or without collagen alpha 3(XI) transcripts. Collagen type XI may therefore exist as homotrimers and/or heterotrimers composed of two collagen alpha(XI) chains in some tissues. The distribution of mRNAs for collagen alpha 2(V) and alpha 1(I) were also studied. Co-expression of collagen type XI, alpha 2(V) and alpha 1(I) mRNAs was found for many tissues. These findings have implications for the possibility of additional chain associations for collagen types XI and V in cross-type heterotrimers within heterotypic fibrils.
The nasal base is very complex secondary to the dynamic relationship between the skin, underlying muscle, and cartilaginous structures. Recently, we have employed a new method for refinement of the nasal base, which we name reduction columelloplasty. This procedure employs a full-thickness diamond-shaped tissue excision between the feet of the medial crura. The incision is carried down through the skin, depressor septi muscle, and adjacent soft tissue. Following en bloc removal, the defect is carefully closed in a vertical orientation, approximating the medial crura of the lower lateral cartilages. As in the open rhinoplasty approach, the scar produced by this technique is of negligible importance if it is closed using proper techniques of skin eversion and early suture removal. We have found this procedure to be an extremely reliable method for narrowing splayed medial crura, increasing the nasolabial angle, modifying the shape of the nares, and for increasing tip projection.
BACKGROUND: It is often difficult to achieve an esthetically pleasing cosmetic match when full-thickness skin grafts from periclavicular, preauricular, or postauricular donor sites are used to repair distal nasal defects. This, in large part, is due to the highly sebaceous nature of the skin on the distal aspect of the nose. OBJECTIVE: Our purpose was to describe the benefits of using donor skin from the conchal bowl to repair defects of the nasal tip. METHODS: The technique of conchal bowl grafting is described. RESULTS: The conchal grafts give an excellent cosmetic result with respect to color and texture match and are time efficient because the donor site can be allowed to heal by secondary intention. CONCLUSION: The conchal bowl offers an esthetically reliable source of donor skin for full-thickness and perichondrial cutaneous grafts to repair defects of the nasal tip.