PubMed · 59081
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1976-07-03. Editorial: Cobalt in severe renal failure.. https://pubmed.ncbi.nlm.nih.gov/59081/
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A 42-year-old patient with a regenerative erythroblastopenic anaemia (7 g % Hb), considered as Pure Red Cell Aplasia (PRCA) is submitted to an immunosuppressive treatment (cyclophosphamide + prednisone). For three times, this treatment gives a complete remission, followed by relapse when medication stopped. Hereafter the patient develops a Myelofibrosis with Myeloid Metaplasia (MMM). Between the different hypothesis, the most probable one seems to be an autoimmune PRCA secondary to MMM but appearing before the latter. This observation allows discussion about the role of immunological phenomens in MMM.
Stress is laid on the seriousness of malaria and the causes of its unusual clinical pictures. Results obtained in the evaluation of G-6-PD, PK, intracellular K and globular resistance, in addition to other parameters, suggest (as pointed out in the literature) that altered cell metabolism may be the primary cause of haemolysis. Attention is also drawn to the lengthy persistance of gametes after gametocidal management in some patients, and the risks that this involves.