PubMed · 5924520
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
F Glenn. 1966. Cholecystectomy.. https://doi.org/10.1016/s0039-6109(16)38029-x
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
OBJECTIVES: Over the past decade, the glial protein S-100beta has been used to detect cerebral injury in a number of clinical settings including cardiac surgery. Previous investigations suggest that S-100beta is capable of identifying patients with cerebral dysfunction after cardiopulmonary bypass. Whether detection of elevated levels S-100beta reflects long-term cognitive impairment remains to be shown. The present study evaluated whether perioperative release of S-100beta after coronary artery operations with cardiopulmonary bypass could predict early or late neuropsychologic impairment. METHODS: A total of 100 patients undergoing elective coronary bypass without a previous history of neurologic events were prospectively studied. To exclude noncerebral sources of S-100beta, we did not use cardiotomy suction or retransfusion of shed mediastinal blood. Serial perioperative measurements of S-100beta were performed with the use of a new sensitive immunoluminometric assay up to 8 hours after the operation. Patients underwent cognitive testing on a battery of 11 tests before the operation, before discharge from the hospital, and 3 months later. RESULTS: No significant correlation was found between S-100beta release and neuropsychologic measures either 5 days or 3 months after the operation. CONCLUSION: Despite using a sensitive immunoluminometric assay of S-100beta, we found no evidence to support the suggestion that early release of S-100beta may reflect long-term neurologic injury capable of producing cognitive impairment.
Anesthesia for endoscopic assessment and treatment of airway problems in infants and children requires a systematic and thoughtful approach. The anesthesiologist and otolaryngologist should have a sound knowledge of the causes of airway obstruction. The anesthesiologist must be aware of the instrumentation likely to be used and the endoscopist must be well informed about the principles of anesthesia. The choice of technique depends upon the needs for each patient, but in most cases, the safest and most controlled method is a gaseous induction with assisted spontaneous respiration and continued maintenance by the inhalational method, supplemented by topically applied local anesthesia.