PubMed · 5953722
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H J Rapp, T Borsos. 1966-12-26. Complement research. Fundamental and applied.. https://pubmed.ncbi.nlm.nih.gov/5953722/
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The complement-dependent cytotoxicity (CDC) crossmatch and the flow cytometry crossmatch (FCXM) are both used prospectively in renal transplantation, and their use is under evaluation in other types of major organ transplantation. The FCXM is the more sensitive method and better predicts outcome in second and subsequent renal allografts. Improved survival has unmasked the detrimental effect of a positive crossmatch on outcome in liver transplantation. Because of the urgent need of liver transplant candidates, it is unrealistic to defer transplantation until a crossmatch-negative donor is found; however, additional therapeutic measures may be taken to improve outcome for crossmatch-positive liver recipients. Some reports suggest that prospective crossmatching may improve outcome for sensitized heart recipients, and, additionally, recent studies have demonstrated that HLA compatibility between donor and recipient is an independent variable affecting survival after heart transplantation, prompting a reassessment of the current practice of transplanting hearts without consideration of the HLA match.
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The authors examined some immunological indicators in a group of female patients with imminent premature delivery and compared them, using statistical methods, with findings in a control group. The objective was to find a possible predictive value of the investigated parameters for the diagnosis of subclinical intraamnial infection as the possible cause of so-called idiopathic premature delivery. In the immunoglobulin classes they did not find significant differences between the two groups. In the group of patients with an imminent premature delivery they found, however, statistically significantly higher levels of the C3 component of complement, of orosomucoid, alpha-2 and gamma-globulins. They compared the results with data in the literature and assume that some immunological indicators can, after confirmation of the results by other authors, serve as the prediction of subclinical intraamnial infection with imminent prematurity.