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PubMed · 5979553

Electron microscope study of pseudoxanthoma elasticum.

K Hashimoto·J DiBella·W F Lever

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Elastic Tissue Humans Microscopy, Electron Pseudoxanthoma Elasticum Journal Article

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K Hashimoto, J DiBella, W F Lever. Electron microscope study of pseudoxanthoma elasticum.. https://pubmed.ncbi.nlm.nih.gov/5979553/

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Pseudoxanthoma elasticum (PXE), a pleiotropic multisystem disorder affecting the skin, eyes, and cardiovascular system, is caused by mutations in the ABCC6/MRP6 expressed primarily in the liver. A question has arisen regarding the pathomechanism of PXE, particularly the "metabolic" versus the "PXE cell" hypotheses. Le Saux et al. have now provided partial support for the notion that PXE is primarily a metabolic disorder.

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