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DDT: interaction with nerve membrane conductance changes.

T Narahashi·H G Haas
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Abstract

The falling phase of action potentials of lobster giant axons is prolonged by DDT; finally a plateau phase is produced like cardiac action potentials. In axons poisoned with DDT, peak transient (sodium) currents associated with step depolarizations are turned off very slowly, and steady-state (potassium) currents are markedly suppressed. These two changes would cause the prolongation of action potentials and are considered the major ionic mechanisms of DDT action.

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AnimalsAxonsCrustaceaDDTElectrophysiologyMembrane PotentialsPotassiumSodiumToxins, BiologicalJournal Article

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T Narahashi, H G Haas. 1967-09-22. DDT: interaction with nerve membrane conductance changes.. https://doi.org/10.1126/science.157.3795.1438

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