PubMed · 6038200
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
M Donelson. 1967. Hemorrhoids.. https://pubmed.ncbi.nlm.nih.gov/6038200/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Addition of chlorpromazine (CPZ) of 100 microM final concentration to fragments of primordial human placenta incubated in vitro with [3H]glycerol results in the following changes in the labelling of various neutral lipids and phospholipids: (1) rapid accumulation of [3H]phosphatidic acid (PA) to a 2.31 +/- 0.12-fold (mean +/- s.d., P < 0.05) higher steady-state level within 5 min; (2) a dramatic, 5-6-fold (5.74 +/- 0.31, P < 0.01) increase in [3H]phosphatidylinositol (PI) synthesis within 5-10 min, followed by progressive PI accumulation; (3) gradual accumulation of [3H]1,2-diacylglycerol (DAG) reaching approximately 1.7-fold (1.72 +/- 0.14, P < 0.05) higher steady-state level at 30 min; and (4) an approximately 20 and 30% decrease in [3H]triacylglycerol (TG) and [3H]phosphatidylcholine (PC) formation, respectively, which begins to become evident between 10-30 min. As dose-response studies indicate, accumulations of PI and DAG are most susceptible to CPZ. They respond in the concentration range of 10-50 microM, while only higher drug concentrations (100-250 microM) affect the synthesis of PA, PC and TG significantly. Finally, dioctanoylethyleneglycol (DOEG), a structural analogue of the diacyl moiety of PA and DAG, selectively inhibits the basal synthesis (0.59 +/- 0.15, P < 0.05) as well as the CPZ-induced rise (0.49 +/- 0.11, P < 0.02) of PI. These results suggest that CPZ-induced increase in the concentrations of PI and 1,2-DAG may interfere with signal-transduction pathways in the placenta of pregnant patients treated with CPZ. Furthermore, DOEG is able to antagonize the CPZ effect which directs lipid biosynthesis towards the formation of PI.
Dopamine is a popular and effective vasopressor agent. However, in the event of overdose with a potent alpha 1-receptor blocker, dopamine may not be effective in treatment of hypotension. A vasopressor that stimulates only alpha-receptors, such as norepinephrine or phenylephrine, may be more appropriate. In our case, dopamine was clearly ineffective, whereas norepinephrine worked well. Our case also demonstrates the importance of carefully monitoring the effectiveness of any vasopressor therapy.