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PubMed · 6088293

Modulation of junctional permeability.

W C De Mello
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Abstract

Changes in intercellular coupling can be accomplished by continuous synthesis and destruction of intercellular channels and through a modulation of unit channel permeability. The increase in free [Ca2+]i caused by activation of sodium-calcium exchange or by metabolic inhibition leads to cell decoupling. In embryonic cells the conductance of the gap junction is strongly dependent on pHi. The exact role of Ca2+ and H+ in the physiological modulation of junctional conductance remains unknown. The cyclic AMP (cAMP)-calcium hypothesis is presented. According to this view, cAMP modulates the junctional permeability through specific kinases. A feedback mechanism between calcium and cAMP might be relevant in the physiological control of junctional conductance.

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AnimalsBucladesineCalciumCell Membrane PermeabilityCyclic AMPElectric ConductivityHeart Conduction SystemHydrogen-Ion ConcentrationIntercellular JunctionsPurkinje FibersJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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W C De Mello. 1984. Modulation of junctional permeability.. https://pubmed.ncbi.nlm.nih.gov/6088293/

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