Alternative RNA processing: determining neuronal phenotype.

M G Rosenfeld; S G Amara; R M Evans

doi:10.1126/science.6089345

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PubMed · 6089345

Alternative RNA processing: determining neuronal phenotype.

M G Rosenfeld·S G Amara·R M Evans

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Abstract

On the basis of an analysis of the human and rat calcitonin genes and of a related gene, alternative RNA processing represents a developmental strategy of the brain to dictate tissue-specific patterns of polypeptide synthesis. This regulation allows the calcitonin gene to generate two messenger RNA's, one encoding the precursor of a novel neuropeptide, referred to as CGRP, which predominates in the brain, and the second encoding the precursor to the hormone calcitonin which predominates in thyroid C cells. The distribution of CGRP in the central and peripheral nervous system and in endocrine and other organ systems suggests potential functions in nociception, ingestive behavior, cardiovascular homeostasis, and mineral metabolism.

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Animals Base Sequence Calcitonin Calcitonin Gene-Related Peptide Cloning, Molecular DNA DNA Restriction Enzymes Genes Nerve Tissue Proteins Neurons Phenotype RNA Processing, Post-Transcriptional RNA, Messenger Rats Journal Article Research Support, Non-U.S. Gov't

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M G Rosenfeld, S G Amara, R M Evans. 1984-09-21. Alternative RNA processing: determining neuronal phenotype.. https://doi.org/10.1126/science.6089345

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