PubMed · 6092700
Simian virus 40 replication pause sites map with the nucleosomes.
Abstract
The locations of replication pause sites in the simian virus 40 minichromosome which were determined by sizing cloned fragments of nascent DNA (Zannis-Hadjopoulos et al., J. Mol. Biol. 165:599-607, 1983) were compared with the positions of simian virus 40 nucleosomes in the genome, as obtained by sequence-directed mapping (G. Mengeritsky and E. N. Trifonov, Nucleic Acids Res. 11:3833-3851, 1983; Mengeritsky and Trifonov, Cell Biophys. 6:1-8, 1984). Clear correlation between these two maps is demonstrated, suggesting that nucleosomes hinder propagation of the replication forks.
Explore related subjects
Keep this discovery
Explore connections, maps & timelines
E N Trifonov, G Mengeritsky. 1984. Simian virus 40 replication pause sites map with the nucleosomes.. https://doi.org/10.1128/jvi.52.3.1011-1012.1984
Cite the original work for its findings. Save a collection to share your selection of sources.